Time-dependent Mechanisms in Beta-cell Glucose Sensing
نویسندگان
چکیده
منابع مشابه
Channel regulation of glucose sensing in the pancreatic beta-cell.
Mammalian beta-cells are acutely and chronically regulated by sensing surrounding glucose levels that determine the rate at which insulin is secreted, to maintain euglycemia. Experimental research in vitro and in vivo has shown that, when these cells are exposed to adverse conditions like long periods of hypoglycemia or hyperglycemia, their capability to sense glucose is decreased. Understandin...
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BACKGROUND Glucose effects on beta cell survival and DNA-synthesis suggest a role as regulator of beta cell mass but data on beta cell numbers are lacking. We examined outcome of these influences on the number of beta cells isolated at different growth stages in their population. METHODS Beta cells from neonatal, young-adult and old rats were cultured serum-free for 15 days. Their number was ...
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Abstract Background Multiple transfusions in thalassemia patients may lead to antibody production against blood group antigens and hemolytic transfusion reaction might occur. In this study, antibody screening test was performed by tube and gel methods to determine the prevalence and specificity of alloantibodies in thalassemia patients. Materials and Methods In this cross-sectional study, overa...
متن کاملGlucose Sensing by the -Cell
process designed to ensure near constant blood glucose levels in the face of increases in supply during meals and varying rates of utilization of the sugar by tissues. Loss of insulin-secreting pancreatic islet cells thus underlies the pathology of Type 1 diabetes (20), whereas cellular dysfunction (25) perhaps compounded by a decrease in total cell mass (7) contributes to Type 2 diabetes (56, ...
متن کاملA time-dependent phenomenological model for cell mechano-sensing.
Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or muscle contraction. In recognition of this fact, experiments have been conducted...
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ژورنال
عنوان ژورنال: Journal of Biological Physics
سال: 2006
ISSN: 0092-0606,1573-0689
DOI: 10.1007/s10867-006-9017-9